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KMID : 1234420100380010077
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Korean Journal of Microbiololgy and Biotechnology
2010 Volume.38 No. 1 p.77 ~ p.83
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Antimicrobial Activity of Fruit of Crataegus pinnatifida Bunge against Multidrug Resistant Pathogenic Pseudomonas aeruginosa and Candida sp
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Ryu Hee-Young
An Seon-Mi
Kim Jong-Sik
Jung In-Chang
Sohn Ho-Yong
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Abstract
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The fructus of Crataegus pinnatifida Bunge (CBF) has been used as medicinal and food source in worldwide. In this study, antimicrobial activity of the methanol extract and its sequential organic solvent fractions of CBF against different pathogenic bacteria and fungi, including multidrug resistant Pseudomonas aeruginosa and Candida sp., were investigated. The methanol extract of CBF was active against various gram-positive and gram-negative bacteria, and the ethylacetate and butanol fractions of CBF showed strong antibacterial activity against Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium, Proteus vulgaris, Escherichia coli and various multidrug resistant Pseudomonas aeruginosa with minimal inhibitory concentration of 1.0~7.5 mg/mL. Also the fractions showed anti-Candida activity against C. albicans, C. kruseis and C. geochares. The methanol extract of CBF and its solvent fractions, except n-hexane fraction, did not show any hemolytic activity against human red blood cell up to 500 μg/mL, respectively. The hemolysis in n-hexane fraction at 500 μg/mL was less than 9.9%. Our results suggest that the CBF could be developed as a potent antibacterial agent, especially for multidrug resistant Pseudomonas aeruginosa
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KEYWORD
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Antibacterial, multidrug resistant Pseudomonas aeruginosa, anti-Candida, fructus of Crataegus pinnatifida Bunge
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